Changes of heme oxygenase-1 and inflammatory factors in patients with end-stage renal failure following hemodialysis.
- Author:
Fan WU
1
;
Lu YU
;
Zhi-min ZHANG
;
Hai-bin SHI
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Blood Urea Nitrogen; C-Reactive Protein; metabolism; Creatinine; blood; Enzyme-Linked Immunosorbent Assay; Female; Heme Oxygenase-1; blood; Humans; Interleukin-6; blood; Kidney Failure, Chronic; blood; therapy; Male; Malondialdehyde; blood; Middle Aged; Renal Dialysis
- From: Journal of Southern Medical University 2007;27(3):368-370
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the changes in heme oxygenase-1 (HO-1), C-reactive protein (CRP), interleukin-6 (IL-6), and malondialdehyde (MDA) levels in patients with end-stage renal failure (ESRF) following hemodialysis.
METHODSThe urea nitrogen and the blood creatinine levels were determined with an automatic biochemistry analyzer, HO-1 and IL-6 levels by enzyme linked immunosorbent assay (ELISA), CRP by chemoluminescence technique, and MDA by thiobarbituric acid assay.
RESULTSHO-1, CRP, IL-6, and MDA levels were significantly elevated in patients with ESRF in comparison with the control group. After hemodialysis, HO-1 and CRP levels increased and IL-6 and MDA levels decreased significantly.
CONCLUSIONIn ESRF patients who have elevated inflammatory factors and HO-1 levels, hemodialysis can increase HO-1 and CRP levels and lower IL-6 and MDA levels.
