Association between environmental risk factor exposure in the first trimester and nonsyndromic cleft lip with or without cleft palate: a case-control study.
- Author:
Mei-hua FU
1
;
Wei CHEN
;
Min-zhu HUANG
;
Xin-yin WU
Author Information
- Publication Type:Journal Article
- MeSH: Case-Control Studies; Cleft Lip; epidemiology; etiology; prevention & control; Cleft Palate; epidemiology; etiology; prevention & control; Female; Folic Acid; administration & dosage; Humans; Maternal Exposure; Pregnancy; Pregnancy Trimester, First; Risk Factors; Stress, Psychological
- From: Journal of Southern Medical University 2007;27(4):436-438
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo identify the environmental risk factors during the first trimester responsible for nonsyndromic cleft lip with or without cleft palate to collect data for prevention of this congenital defect.
METHODSA hospital-based case-control study was conducted to identify the risk factors by means of field investigation with standardized questionnaires. Single factor analysis and logistic regression of the data are performed using SPSS 13.0 software.
RESULTSMultifactorial analysis revealed that folic acid was significantly associated with lowered incidence of nonsyndromic cleft lip with or without cleft palate (OR=0.100, 95%CI: 0.032-0.312), whereas maternal infection (OR=4.155, 95%CI: 2.166-7.970), poisonous chemical exposure (OR=6.816, 95%CI: 2.528-18.381) and emotional stress (OR=3.250, 95%CI: 1.477-7.154) were risk factors for this defect.
CONCLUSIONSSufficient follic acid intake and prevention of infection and poisonous chemical exposure during the first trimester are measures to reduce the risks of nonsyndromic cleft lip with or without cleft palate.
