Changes of CD4+CD28- T cell and CD4+CD25+ regulatory T cell subsets in patients with coronary heart disease.
- Author:
Yi-qiao ZHAO
1
;
Qiang FU
;
Zhi-liang LI
;
Quan-neng YAN
;
Hong-chao WU
;
Fei MIAO
;
Yong-heng LÜ
;
Ying-feng LIU
Author Information
- Publication Type:Journal Article
- MeSH: Aged; Angina, Unstable; immunology; CD28 Antigens; CD4-Positive T-Lymphocytes; immunology; Case-Control Studies; Coronary Disease; immunology; Female; Humans; Interleukin-2 Receptor alpha Subunit; Male; Middle Aged; T-Lymphocyte Subsets; immunology; T-Lymphocytes, Regulatory; immunology
- From: Journal of Southern Medical University 2007;27(4):474-476
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the changes of CD4(+)CD28(-) T cell and CD4(+)CD25(+) regulatory T cell (Treg) subsets in patients with coronary artery disease (CAD).
METHODSTwenty-eight patients with angiographically established CAD were recruited in this study, including 16 with unstable angina (UA group) and 12 with stable angina (SA group). Eleven patients with chest pain syndrome served as the control group. The proportions of peripheral CD4(+)CD28(-) T cells and CD4(+)CD25(+) Treg subsets were determined with fluorescence-activated cell sorting (FACS).
RESULTSThe proportions of CD4(+)CD25(+) Treg were significantly lower in UA group (6.55-/+2.45%) than in SA (14.01-/+4.92%) and control groups (13.55-/+3.87%). The proportions of CD4(+)CD28(-) T cells were significantly higher in UA group (10.55-/+4.76%) than in SA (2.64-/+1.33%) and control (2.75-/+1.55%) groups.
CONCLUSIONAlterations of circulating T-lymphocyte subsets occur in patients with UA. The changes of Treg and CD4(+)CD28(-) T cells may lead to breakdown of peripheral autoimmune tolerance and play an important role in the development and progression of CHD.
