Correlation between MHC class I-related chain A gene *008 allele and human cytomegalovirus infection.
- Author:
Bai-sheng HUANG
1
;
Qi-zhi LUO
;
Bing MEI
;
Ping YU
Author Information
- Publication Type:Journal Article
- MeSH: Alleles; Cytomegalovirus Infections; genetics; Gene Frequency; Genetic Predisposition to Disease; Genotype; Histocompatibility Antigens Class I; genetics; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; genetics; virology
- From: Journal of Southern Medical University 2007;27(4):509-511
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the correlation between MHC class I-related chain A (MICA) gene *008 allele and human cytomegalovirus (HCMV) infection.
METHODSMICA*008 allele was detected in 86 patients with chronic granulocytic leukemia and 81 unrelated normal individuals by way of sequence-specific primers (PCR-SSP). Anti-HCMV IgM was also detected in the sera of these subjects with enzyme linked immunosorbent assay (ELISA).
RESULTSMICA*008 allele frequency was lower in patients with chronic granulocytic leukemia than in the control group (22.2% vs 34.3%, Chi(2)=4.98, P<0.05). The infection rate of HCMV was significantly higher in those individuals with genotype of MICA*008 (-) than in those with MICA*008 (+), and moderate correlation was suggested between MICA*008 and HCMV infection (C=0.5829, 0.6142).
CONCLUSIONIndividuals with MICA*008 positivity is not liable to HCMV infection, but those with MICA*008 (-) can be vulnerable to HCMV infection, suggesting an inverse correlation between MICA*008 allele with HCMV.
