Expression of hypoxia-inducible factor-1alpha in endometriosis.
- Author:
Xu REN
1
;
Yuan-li HE
;
Shi-lei PAN
;
Dong-xian PENG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Endometriosis; genetics; Endometrium; metabolism; Female; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; genetics; metabolism; Menstrual Cycle; metabolism
- From: Journal of Southern Medical University 2007;27(4):538-540
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo detect the expression of hypoxia-inducible factor-1alpha(HIF-1alpha) in endometriosis and explore the possible role of HIF-1alpha in the pathogenesis of endometriosis.
METHODSImmunohistochemistry was performed to examine the expression of HIF-1alpha in 20 normal endometrium, 20 ectopic endometrium and 68 eutopic endometrium specimens from 68 endometriosis patients, and the results were analyzed statistically.
RESULTSThe expression of HIF-1alpha was significantly increased in ectopic endometrium than in normal endometrium (P<0.01), and the expression did not undergo changes with the normal menstrual cycle in the three types of endometrium.
CONCLUSIONHIF-1alpha expression increases in ectopic endometrium, suggesting that HIF-1alpha plays an important role in the pathogenesis of endometriosis.
