Comparison of transdermal permeation in vitro of lidocaine tincture and microemulsion.
- Author:
Liang HUANG
1
;
Zhi-liang CHEN
;
Guo-feng LI
;
Xiao-liang ZHU
;
Chan LIU
Author Information
- Publication Type:Journal Article
- MeSH: Administration, Cutaneous; Anesthetics, Local; administration & dosage; Drug Compounding; Drug Delivery Systems; Emulsions; administration & dosage; Lidocaine; administration & dosage; Skin Absorption
- From: Journal of Southern Medical University 2007;27(4):541-542
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo compare lidocaine tincture and microemulsion for their transdermal permeation.
METHODSThe experimental model for percutaneous administration of lidocaine preparations in vitro was prepared using modified Franz diffusion cell.
RESULTSThe accumulated infiltration amount of lidocaine microemulsion in unit area was higher than that in its cream or tincture preparations.
CONCLUSIONThe transdermal permeation of lidocaine microemulsion in vitro can be more efficient than that of the tincture preparation, and the permeation is linearly dependent on the dose administered within a certain range.
