Protective effects of lidocaine against lung injury after hemorrhagic shock in rabbits.
- Author:
Luo-yang RUAN
1
;
Chun-shui LIN
;
Ying-ying LIU
;
Miao-ning GU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Disease Models, Animal; Lidocaine; pharmacology; Lung; drug effects; metabolism; Lung Injury; prevention & control; Malondialdehyde; blood; Rabbits; Shock, Hemorrhagic; drug therapy; Superoxide Dismutase; blood
- From: Journal of Southern Medical University 2007;27(4):543-545
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the protective effect of lidocaine against lung injury after hemorrhagic shock in rabbits.
METHODSEighteen healthy rabbits were randomly divided into 3 groups (n=6), namely lidocaine group (group L), hemorrhagic shock group (group H) and control group (group C). Hemorrhagic shock model was established in rabbits in groups L and H, and the venous blood samples were collected for measurement of plasma malondialdehyde (MDA) and superoxidedismutase (SOD) before phlebotomy (T0), 2 h after hemorrhagic shock (T1) and 2 h after resuscitation (T2). Blood samples were also taken for measurement of MDA and SOD at the same time points in group C. The wet to dry weight ratio of the lung (W/D) was measured at T2.
RESULTSMDA level was significantly lower while SOD level significantly higher in group L than in group H (P<0.05). The W/D ratio in group L was reduced significantly as compared with that in group H (P<0.05).
CONCLUSIONLidocaine can remarkably alleviate lung injury after hemorrhagic shock by inhibiting MDA production and increasing SOD content.
