Treatment of recurrent condyloma acuminatum with solid lipid nanoparticle gel containing podophyllotoxin: a randomized double-blinded, controlled clinical trial.
- Author:
Fang-ming XIE
1
;
Kang ZENG
;
Zhi-liang CHEN
;
Guo-feng LI
;
Zhong-fang LIN
;
Xiao-liang ZHU
;
Le-dong SUN
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Condylomata Acuminata; drug therapy; pathology; Double-Blind Method; Drug Delivery Systems; Female; Gels; Humans; Lipids; chemistry; Male; Middle Aged; Nanoparticles; chemistry; Podophyllotoxin; administration & dosage; chemistry; Secondary Prevention; Treatment Outcome; Young Adult
- From: Journal of Southern Medical University 2007;27(5):657-659
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the clinical efficacy and safety of podophyllotoxin delivered via solid lipid nanoparticle gel for topic treatment of recurrent condyloma acuminatum.
METHODSIn a randomized double-blinded study, podophyllotoxin solid lipid nanoparticles gel and routine podophyllotoxin gel preparation was applied respectively for treatment of 97 volunteer patients with recurrent condyloma acuminatum. The therapeutic effect, condyloma acuminatum relapse following the treatment and adverse effect were evaluated.
RESULTSThe wart clearance rate in the condyloma acuminatum patients in the first treatment course with podophyllotoxin solid lipid nanoparticle gel reached 97.1%, close to that with the routine preparation of 90.6%, but the nanoparticle preparation significantly reduced the recurrence rate and adverse effect (P<0.01).
CONCLUSIONPodophyllotoxin delivered via solid lipid nanoparticle gel can effectively clear condyloma acuminatum and reduce its recurrence rate with only mild, tolerable adverse effect.
