Identification of a novel candidate gene KLRC1 within the putative susceptibility locus for systemic lupus erythematosus at 12p12.3-13.2 in a Chinese cohort.
- Author:
Li-li REN
1
;
Fu-rong LI
;
Dong-zhou LIU
;
Hui QI
;
Zhi-bin OUYANG
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Asian Continental Ancestry Group; genetics; China; Chromosomes, Human, Pair 12; genetics; Female; Gene Expression Profiling; Genetic Predisposition to Disease; Humans; Lupus Erythematosus, Systemic; ethnology; genetics; pathology; Male; Middle Aged; NK Cell Lectin-Like Receptor Subfamily C; genetics; Reverse Transcriptase Polymerase Chain Reaction; Severity of Illness Index; Young Adult
- From: Journal of Southern Medical University 2007;27(5):672-674
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo identify the candidate genes within the putative susceptibility locus for systemic lupus erythematosus (SLE) at 12p12.3-13.2.
METHODSKLRC1 was selected as the candidate gene according to the results of previous gene chip studies. TaqMan real-time quantitative PCR was performed for detecting KLRC1 mRNA expression in 55 SLE patients and 30 controls.
RESULTS AND CONCLUSIONKLRC1 mRNA expression was significantly higher in the mononuclear cells and T cells of SLE patients than in the healthy controls (P<0.01), but showed no significant difference in the B cells. No obvious correlation was found between the SLE disease activity index (SLEDAI) and KLRC1expression level, suggesting that KLRC1 can be a probable candidate gene for SLE on 12p12.3-13.2, but which is not associated with the disease activity.
