CT perfusion study of acute local cerebral infarction in rhesus monkeys.
- Author:
Zhuo-kai HE
1
;
Yi-kai XU
;
Wei-jia QIU
;
Yan-xian DENG
;
Zhi-peng ZHOU
;
Zhi-hong HUANG
;
Fei-ling FENG
;
Ying WEI
;
Rui-jing GAN
;
Jun-xiong YU
Author Information
- Publication Type:Journal Article
- MeSH: Acute Disease; Animals; Brain; diagnostic imaging; Brain Ischemia; diagnosis; Cerebral Infarction; diagnosis; Contrast Media; administration & dosage; Early Diagnosis; Macaca mulatta; Perfusion; Sensitivity and Specificity; Tomography, X-Ray Computed; methods
- From: Journal of Southern Medical University 2007;27(5):720-724
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the value of CT perfusion in early diagnosis and management of superacute local cerebral infarction in rhesus monkeys.
METHODAcute local cerebral infarction was induced in the rhesus monkeys during digital subtraction angiography (DSA) by introduction of pale thrombus prepared from autologous blood into the M1 branch of the middle cerebral artery (MCA). Plain CT scan and CT perfusion scanning were performed at different time points before and after DSA operation, and the results were analyzed in conjunction with the pathologic changes.
RESULTSIschemic lesions were displayed on CT perfusion images, which showed local hypoperfusion, reduced cerebral blood flow and volume, and mean transit time delay in the compromised area. Local hypointense infarct area was identified in plain CT scan 24 h after the DSA operation, and the results were in good agreement with pathological examination during autopsy.
CONCLUSIONCT perfusion imaging of the brain can accurately capture the cerebral perfusion deficits in acute ischemic stroke before morphologic changes take place, and therefore provides good means for thrombolytic treatment evaluation of stroke.
