Impact of chronic prostatitis/chronic pelvic pain syndrome on sperm DNA fragmentation and nucleoprotein transition.
- Author:
Yang-Yang HU
1
;
Shun-Shun CAO
;
Jie-Qiang LÜ
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Case-Control Studies; DNA Fragmentation; Humans; Male; Nucleoproteins; genetics; Prostatitis; genetics; Semen Analysis; Sperm Count; Sperm Motility; Young Adult
- From: National Journal of Andrology 2013;19(10):907-911
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the impact of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) on sperm DNA fragmentation and nucleoprotein transition.
METHODSBased on the recommended methods in the WHO Laboratory Manual for the Examination and Processing of Human Semen (5th ed), we conducted routine semen analysis for 65 CP/CPPS patients and 30 healthy men. We also analyzed the results of papanicolaou staining, sperm DNA fragmentation and sperm nucleoprotein transition.
RESULTSCompared with the healthy control males, the CP/CPPS patients showed significant decreases in sperm concentration ([134.05 +/- 99.80] vs [94.75 +/- 92.07]) x 10(6)/ml, P <0.05), the percentage of morphologically normal sperm ([7.26 +/- 2.28] vs [5.61 +/- 3.40]%, P <0.05) and sperm progressive motility ([59.18 +/- 16.06] vs [47.68 +/- 17.62]%, P<0.05), but dramatic increases in sperm DNA fragmentation ([22.92 +/- 11.51] vs [43.58 +/- 17.07%, P<0.01) and sperm nucleoprotein transition ([23.26 +/- 5.97] vs [32.14 +/- 8.79]%, P<0.01).
CONCLUSIONCP/CPPS significantly reduces sperm quality and male fertility.
