Regulation of the self-renewal and differentiation of spermatogonial stem cells.
- Author:
Dong-Mei LI
1
;
Xiao-Dong QIN
2
Author Information
1. Laboratory of Immunology and Reproductive Biology, Nanjing University School of Medicine, Nanjing, Jiangsu 210093, China. lidm@nju.edu.cn
2. Laboratory of Immunology and Reproductive Biology, Nanjing University School of Medicine, Nanjing, Jiangsu 210093, China.
- Publication Type:Journal Article
- MeSH:
Adult Stem Cells;
cytology;
Cell Differentiation;
Cells, Cultured;
Humans;
Male;
Spermatogenesis;
Spermatogonia;
cytology;
Stem Cell Transplantation
- From:
National Journal of Andrology
2013;19(11):963-967
- CountryChina
- Language:Chinese
-
Abstract:
Spermatogonial stem cells (SSCs) play an important role in spermatogenesis and have a unique mode of replication. A single SSC can produce two differentiating cells, or one stem cell and one differentiating cell. The self-renewal and differentiation of SSCs are precisely regulated as relating the niche of SSCs, glial cell line-derived neurotrophic factor, and several signaling pathways. This article reviews the self-renewal and differentiation of SSCs and their regulation mechanisms, which may offer a deeper insight into spermatogenesis and male infertility and pave a theoretical ground for studying testicular tumorigenesis and searching for new potential approaches to the treatment of testicular cancer and other related diseases.
