Expressions of differential proteins in the expressed prostatic secretion of patients with III A chronic prostatitis.
- Author:
Xiao-Fan DAI
1
;
Kai-Min GUO
1
;
Cong-Qi DU
2
;
Ling-Yun LIU
1
;
Fu-Biao LI
1
;
Hong-Liang WANG
1
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Body Fluids; metabolism; Case-Control Studies; Chronic Disease; Defensins; metabolism; Endothelin-1; metabolism; Humans; Male; Prostate; secretion; Prostatitis; classification; metabolism; Young Adult
- From: National Journal of Andrology 2013;19(9):780-784
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the expressions of differential proteins in the expressed prostatic secretion (EPS) of patients with III A chronic prostatitis and healthy men.
METHODSWe collected EPS samples from 35 patients with III A chronic prostatitis and 18 age-matched healthy men, and detected the differentially expressed proteins in EPS by MALDI-TOF/MS. Based on the data obtained, we conducted a statistical analysis on the mass-to-charge (m/z) ratios of different proteins and a retrieval analysis on the relevant proteins using the protein database.
RESULTSIn the comparative studies of the III A chronic prostatitis patients and healthy men, 5 proteins were detected as at least 2-fold differentially expressed, which were probably brevinin-2Eg, big endothelin-1, alpha-defensin 15, beta-defensin 134 and prostatic steroid-binding protein C2. The m/z ratios were significantly up-regulated in 3 372, 3 487, 425 and 5 325 Da proteins (P < 0.01) and down-regulated in 10631Da (P < 0.01).
CONCLUSIONProteins are differentially expressed in the EPS of III A chronic prostatitis patients and healthy men, and these proteins may be significantly correlated with the development and progression of III A chronic prostatitis.
