The role of miRNAs in androgen-independent progression of prostate cancer.
- Author:
Jie YANG
1
;
Jia-Yi ZHANG
1
;
Ning-Hong SONG
1
Author Information
1. Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China.
- Publication Type:Journal Article
- MeSH:
Androgens;
pharmacology;
Humans;
Male;
MicroRNAs;
metabolism;
Prostatic Neoplasms;
metabolism
- From:
National Journal of Andrology
2013;19(9):831-834
- CountryChina
- Language:Chinese
-
Abstract:
MicroRNAs are a kind of small non-coding single-stranded RNA molecules that negatively regulate the gene expression by binding to imperfect complementary sites in the 3' untranslated region of targeted mRNAs at the post-transcriptional level. Aberrant expressions of some miRNAs like miR-221/222, miR-146a and miR-125b have been found to be significantly associated with androgen-independent progression of prostate cancer. By analyzing the aberrant expressions and regulation mechanisms of miRNAs in cell lines, tissues and peripheral blood samples, we hope to provide a new theoretic base for the clinical diagnosis and treatment of androgen-independent prostate cancer.
