Progress in researches on male immunocontraception.
- Author:
Qiong YU
1
;
Hong-Gang LI
2
Author Information
1. Research Institute of Family Planning, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China. cmuyuqiong@163.com
2. Research Institute of Family Planning, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.
- Publication Type:Journal Article
- MeSH:
Antigens;
immunology;
Contraception, Immunologic;
methods;
Contraceptive Agents, Male;
immunology;
Humans;
Male;
Vaccines;
immunology
- From:
National Journal of Andrology
2013;19(12):1129-1132
- CountryChina
- Language:Chinese
-
Abstract:
The ideal goal of male immunocontraception is to develop a safe, effective, convenient, acceptable and reversible contraceptive vaccine. Current studies mainly focus on screening the most suitable target antigens from reproductive hormones and sperm functional proteins for the development of immuno contraceptive vaccines. The vaccine targeting reproductive hormones has not been widely used due to its different degrees of side effects and complicated operation. Recent studies show the practicability and applicability of the immuno contraceptive vaccine targeting sperm specific antigens, but its development is confronted with many challenges, such as how to select appropriate target antigens, how to enhance the immunogenicity of the vaccine, how to choose appropriate drug-delivery ways, how to reduce its side effects, and how to decrease its cost.
