Therapeutic effect of allogeneic hematopoietic stem cell transplantation with reduced-intensity conditioning regimens on hematological malignancies.
- Author:
Xiao YUAN
1
;
Zi-Min SUN
;
Hui-Lan LIU
;
Liang-Quang GENG
;
Zu-Yi WANG
;
Juan TONG
;
Wen YAO
Author Information
1. Department of Hematology, Anhui Provincial Hospital, Anhui Medical University, Hefei 230001, Anhui Province, China.
- Publication Type:Journal Article
- MeSH:
Adult;
Cyclosporine;
administration & dosage;
Female;
Graft vs Host Disease;
prevention & control;
Hematologic Neoplasms;
therapy;
Hematopoietic Stem Cell Transplantation;
methods;
Humans;
Lymphocyte Transfusion;
Male;
Middle Aged;
Mycophenolic Acid;
administration & dosage;
analogs & derivatives;
Transplantation Conditioning;
methods
- From:
Journal of Experimental Hematology
2008;16(3):614-617
- CountryChina
- Language:Chinese
-
Abstract:
This study was aimed to investigate the therapeutic efficiency and complications after allo-hematopoietic stem cell transplantation (allo-HSCT) with reduced-intensity conditioning regimens in hematologic malignancies. 10 patients (6 CML patients, 2 AML patients, 1 ALL patient and 1 NHL patient) underwent related allogeneic hematopoietic stem cell transplantation with reduced-intensity conditioning regimens. The conditioning regimens consisted of "FLU + CY + TBI" basically and was appropriately improved in accordance with status of patients. Cyclosporin A (CsA) and mycophenolate mofetil (MMF) were used to prevent the graft-versus-host disease (GVHD). Detection of bone marrow cells, chromosomes, fused gene, ABO blood group and STR-PCR were used to observe engraftment, relapse, GVHD, transplantation- related complications (TRC) after transplantation and to evaluate patients quality of life. The results showed that the 10 patients successfully accepted the transplantation and their primary diseases were cured. In one patient, severe pulmonary infection happened, and in another one CMV infection occurred. Grade IV of acute GVHD occurred in one case and grade I of acute GVHD in 2 cases, the no chronic GVHD appeared. 5 patients relapsed after transplantation at various time points, the donor lymphocytes infusion (DLI) or drugs rescued these 5 patients. During median follow-up of 5 - 35 months, 2 out of which died, 8 survived, the overall survival rate was 80%, and the survivors live in a high-quality life. In conclusion, the hematopoietic stem cell transplantation with reduced intensity conditioning regimens was feasible with relatively low toxicity for recipients. GVHD and TRC were low, and life quality of patients after transplantation was high. DLI could cure the primary diseases even relapsed after transplantation.
