Polymorphism of LW blood group gene in Chinese population.
- Author:
Yu-Qing SU
1
;
Qiong YU
;
Xu LIU
;
Yan-Lian LIANG
;
Tian-Li WEI
Author Information
1. Shenzhen Blood Center, Shenzhen 518035, Guangdong Province, China. syq-susan@yahoo.com.cn
- Publication Type:Journal Article
- MeSH:
Alleles;
Asian Continental Ancestry Group;
genetics;
Blood Donors;
Blood Group Antigens;
genetics;
Cell Adhesion Molecules;
genetics;
Exons;
genetics;
Homozygote;
Humans;
Polymorphism, Genetic;
Sequence Analysis, DNA
- From:
Journal of Experimental Hematology
2008;16(3):691-693
- CountryChina
- Language:Chinese
-
Abstract:
In order to study the polymorphism of Landsteiner-Wiener (LW) blood group gene in Chinese population, peripheral blood samples anticoagulated with EDTA from 160 unrelated volunteer blood donors were randomly collected, and genomic DNA were extracted. 160 DNA samples were analyzed for exon 1 of LW gene by direct DNA sequencing, and detected for LWa/LWb allele by improved PCR-SSP genotyping. The results showed that all LW allele in 160 donors were LWa homozygous, and the LWa allele occurred commonly. In conclusion, LWa allele occurs with incidence of 100% of donors in this study, while LWb allele has not been found in Chinese population.
