Evaluation of chromosomal abnormalities in non-Hodgkin's lymphomas - review.
- Author:
Lei ZHANG
1
;
Xiao-Ying ZHAO
Author Information
1. Department of Hematology, The Second Hospital, Zhejiang University Medical College, Hangzhou 310006, Zhejiang Province, China.
- Publication Type:Journal Article
- MeSH:
Chromosome Aberrations;
Chromosomes, Human, Pair 11;
Chromosomes, Human, Pair 14;
Humans;
Lymphoma, Non-Hodgkin;
genetics
- From:
Journal of Experimental Hematology
2008;16(3):717-720
- CountryChina
- Language:Chinese
-
Abstract:
Non-Hodgkin's lymphoma (NHL) is a heterogenous disease from various resources and biological characters. Many researches indicated molecular abnormal characteristics in patients with NHL. Currently, NHLs are diagnosed according to the World Health Organisation classification. With the advances in molecular biology and cytogenetics, the cell as a morphological and functional unit has become essential in the diagnosis, therapy and prognosis of lymphoma. The signification of abnormal karyotypes has been more and more focused on, and great progression has been made. Accepting the pitfalls of conventional cytomorphology and immunophenotype, this review emphasizes molecular abnormalities in non -Hodgkin's lymphomas, which are not only a molecular characterization, but also an indicator to predict prognosis and response to treatment.
