Correlation of chemokine CCL-2/MCP-1 level in the plasma with aGVHD and idiophathic pneumonia syndrome after allogeneic hematopoietic stem cell transplantation.
- Author:
Min OUYANG
1
;
Han-Yun REN
;
Yue YIN
;
Zhi-Xiang QIU
;
Xi-Nan CEN
;
Li-Hong WANG
;
Jin-Ping OU
;
Wen-Sheng WANG
;
Mang-Ju WANG
;
Yuan LI
;
Yong-Jin SHI
Author Information
1. Department of Hematology, Peking University First Hospital, Beijing 100034, China.
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
Chemokine CCL2;
blood;
Child;
Child, Preschool;
Female;
Graft vs Host Disease;
blood;
Hematopoietic Stem Cell Transplantation;
adverse effects;
Humans;
Lung Diseases, Interstitial;
blood;
etiology;
Male;
Middle Aged;
Syndrome;
Young Adult
- From:
Journal of Experimental Hematology
2008;16(4):838-842
- CountryChina
- Language:Chinese
-
Abstract:
The aim of this study was to investigate the relationship between the plasma levels of chemokine CCL-2/MCP-1 and acute graft-versus-host disease (aGVHD) and/or idiopathic pneumonia syndrome (IPS) after allogeneic hematopoietic stem cell transplantation (allo-HSCT). ELISA assays were used to detect the plasma level of CCL-2/MCP-1 of 22 patients who received allo-HSCT, including 14 patients without or with grade I, 8 patients with grade II - IV aGVHD, respectively. 8 out of 22 patients were also diagnosed with IPS clinically. The dynamic changes of the plasma levels of CCL-2/MCP-1 chemokine and its correlation with aGVHD and/or IPS were analysized retrospectively. The results showed that the plasma levels of CCL-2/MCP-1 in the patients with moderate and serious aGVHD (grade II - IV) significantly increased, as compared with that prior to allo-HSCT (p < 0.05). The plasma levels of CCL-2/MCP-1 in the patients with aGVHD and/or IPS were higher significantly than those without any of these complications (p = 0.001). The retrospective analysis indicated that the plasma levels of CCL-2/MCP-1 in the patients with IPS significantly increased (p = 0.006). It is concluded that plasma level of CCL-2/MCP-1 correlates with aGVHD and/or IPS, and plays a role in the pathogenesis of these complications.
