Recent advances of CD4(+)CD25(+) regulatory T cells in pathogenesis of idiopathic thrombocytopenic purpura - review.
- Author:
Lu-Juan ZHANG
1
;
Yu ZHANG
Author Information
1. Department of Hematology, The second Affiliated Hospital, Kunming 650101, Yunnan Province, China.
- Publication Type:Journal Article
- MeSH:
Forkhead Transcription Factors;
physiology;
Humans;
Purpura, Thrombocytopenic;
etiology;
immunology;
T-Lymphocytes, Regulatory;
immunology
- From:
Journal of Experimental Hematology
2008;16(4):950-953
- CountryChina
- Language:Chinese
-
Abstract:
CD4(+)CD25(+) regulatory T cells are thought to be a subgroup of cells which have the function of immune suppression. 5 to 10 percentage of peripheral CD4(+) T cells and 1% - 2% of peripheral mononuclear cells are CD4(+)CD25(+) regulatory T cells in mouse or healthy human. They can suppress immune response through many pathways and sustain the stabilization of internal environment. Idiopathic thrombocytopenic purpura is a kind of autoimmunity disease which mainly has a manifestation of hemorrhage in some locations such as skin, mucosa or viscera. Recent findings support that CD4(+)CD25(+) regulatory T cells are relevant to the morbidity of idiopathic thrombocytopenic purpura. In this review, the recent advance on characteristics and function of CD4(+)CD25(+) regulatory T cells, pathogenesis of idiopathic thromocytopenic purpura and role CD4(+)CD25(+) regulatory T cells in pathogenesis of idiopathic thrombocytopenic purpura were summarized.
