Application of NOD/SCID mice in research of experimental hematology - review.
- Author:
Wen-Jun YU
1
;
Wen-Hua YANG
;
Zhe-Xin SHI
;
Xiang-Dong YANG
;
Hui-Juan WANG
Author Information
1. Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Disease Models, Animal;
Hematology;
methods;
Leukemia;
Mice;
Mice, Inbred NOD;
Mice, SCID;
Models, Animal;
Research;
trends
- From:
Journal of Experimental Hematology
2008;16(4):964-968
- CountryChina
- Language:Chinese
-
Abstract:
NOD/SCID (non-obese diabetic/severe combined immunodeficient) mice are immune deficient mice which are made by backcross of severe combined immunodeficient mice with non-obese diabetic mice strains. NOD/SCID mice are both innate immune deficiencies and lack of T and B lymphocytes. Various tumor cells can be implanted in this kind of mice, the rejection and graft-versus-host disease (GVHD) occur fewer. Therefore, NOD/SCID mice gradually become a useful tool for the study on Experimental Hematology. This paper comprehensively reviews the biological characteristics of NOD/SCID mice, the establishment of human leukemia model, stem cell transplantation, drug research, deficiency and improvement of NOD/SCID mice in application for study.
