Preliminary study on Id4 as a reporter for all patients before relapse.
- Author:
Yu ZHAO
1
;
Hong-Hua LI
;
Li-Ping DOU
;
Yu JING
;
Quan-Shun WANG
;
Li YU
Author Information
1. Department of Hematology, PLA General Hospital, Beijing 100853, China.
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
DNA Methylation;
Female;
Humans;
Inhibitor of Differentiation Proteins;
genetics;
Male;
Middle Aged;
Precursor Cell Lymphoblastic Leukemia-Lymphoma;
diagnosis;
genetics;
Promoter Regions, Genetic;
Recurrence;
Young Adult
- From:
Journal of Experimental Hematology
2008;16(5):990-992
- CountryChina
- Language:Chinese
-
Abstract:
This study was purposed to investigate the feasibility of inhibitor of DNA banding 4 (Id4) as a reporter for acute lymphoblastic leukemia (ALL) patients before their clinical relapse. Id4 promoter at methylation status was detected by MS-PCR in bone marrow samples from the ALL patients who had been in their complete remission (CR) for 6 to 8 months with follow-up period of at least three months. The results showed that Id4 methylation were found in 20 out of all 32 patients (62.5%). The remainder 12 patients were fourd Id4 unmethylated, 1 case out of whom relapsed within the next 3-month of follow-up (8.33%), while 10 out of 20 patients (50%) with Id4 methylation relapsed within the same follow-up period. Existence of high risk factors at de novo diagnosis didn't correlated with the Id4 methylation status. In conclusion, Id4 could be regard as a reporter for ALL patients before their relapse.
