Efficacy and safety of oral vardenafil in the treatment of erectile dysfunction.
- Author:
Tianming PAN
1
;
Shenrong ZHUANG
;
Hongming MA
;
Kai HONG
;
Wenhao TANG
Author Information
- Publication Type:Journal Article
- MeSH: Administration, Oral; Adult; Aged; Double-Blind Method; Erectile Dysfunction; drug therapy; Humans; Imidazoles; adverse effects; therapeutic use; Male; Middle Aged; Phosphodiesterase Inhibitors; adverse effects; therapeutic use; Piperazines; adverse effects; therapeutic use; Sulfones; adverse effects; therapeutic use; Triazines; adverse effects; therapeutic use; Vardenafil Dihydrochloride
- From: National Journal of Andrology 2004;10(12):955-959
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the efficacy and safety of vardenafil on men with erectile dysfunction (ED) of various etiologies.
METHODSA total of 88 men with mild to severe erectile dysfunction were enrolled in the randomized, double-blind, placebo-controlled, fixed-dose trial of 12 weeks of treatment with either placebo or 5, 10 and 20 mg of vardenafil.
RESULTSThis study indicated that vardenafil dosages of 5, 10 and 20 mg were significantly superior to placebo for the treatment of ED, on the basis of the primary study endpoints of the EF domain score of the IIEF, diary-recorded success rates for penetration and maintenance of erection during the intercourse and the GAQ. Vardenafil was well tolerated. The incidence of adverse events was higher for vardenafil than for placebo.
CONCLUSIONOral vardenafil therapy has a high efficacy and a low incidence of adverse events for ED patients with mixed etiologies.
