Treatment of experimental chronic bacterial prostatitis with free-radical scavenger in rats.
- Author:
Shao-bo XU
1
;
Shi-wen LI
;
Xin-min ZHENG
;
Li-quan HU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Ascorbic Acid; therapeutic use; Chronic Disease; Free Radical Scavengers; therapeutic use; Male; Malondialdehyde; metabolism; Prostatitis; drug therapy; metabolism; Random Allocation; Rats; Rats, Sprague-Dawley; Sulfasalazine; analogs & derivatives; therapeutic use; Superoxide Dismutase; metabolism
- From: National Journal of Andrology 2005;11(1):47-49
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the efficacy of free-radical scavenger in the treatment of chronic bacterial prostatitis (CBP).
METHODSFifty-eight healthy male rats were randomly divided into a control group and four model groups (Groups A, B, C and D). The chronic prostatitis model was established in the latter groups through injecting E. coli into the ventral robe of the prostate according to document. Group A was untreated, Group B treated with free-radical scavenger vitamin C, Group C with salicylazosulfapyridine (SASP), Group D with SASP and vitamin C. Superoxide dismutase (SOD) and malondialdehyde (MDA) examinations were conducted in each group 2 months later.
RESULTSVitamin C could significantly increase the level of SOD and decrease the level of MDA. There was significant difference between the model groups and the control one, as well as between the treated groups and the untreated one, but none among the treated groups.
CONCLUSIONFree-radical scavenger may be useful for the treatment of chronic bacterial prostatitis.
