Distribution of HCV genotypes in volunteer blood donors in Guangzhou.
- Author:
Han-shen YE
1
;
Ru XU
;
Min WANG
;
Xia RONG
;
Wen-feng HUA
;
Xin YE
;
Guang-ping RUO
;
Yong-shui FU
Author Information
- Publication Type:Journal Article
- MeSH: Blood Donors; China; Genotype; Hepacivirus; classification; genetics; isolation & purification; Humans; Phylogeny; RNA, Viral; genetics; Sequence Analysis, DNA
- From: Journal of Southern Medical University 2010;30(12):2655-2657
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo determine the distribution of HCV genotypes among volunteer blood donors in Guangzhou.
METHODSSix-nine HCV RNA-positive samples were collected from volunteer blood donors in Guangzhou. NS5B fragments of HCV were amplified followed by DNA sequencing and phylogenetic analysis.
RESULTSHCV genotypes were determined for 67 samples. Among them, the subtypes 1b, 2a, 3a, 3b, 6a and 6n were detected at the frequencies of 37.31%, 4.48%, 7.46%, 4.48%, 44.78% and 1.49%, respectively.
CONCLUSIONHCV 1b and 6a are the most predominant two subtypes among volunteer blood donors in Guangzhou.
