Expression of c-myb in reflux esophagitis, Barrett esophagus and esophageal adenocarcinoma.
- Author:
Chun-rong REN
1
;
Lei DONG
;
Xiao-yan GUO
Author Information
- Publication Type:Journal Article
- MeSH: Adenocarcinoma; metabolism; pathology; Adult; Aged; Barrett Esophagus; metabolism; pathology; Esophageal Neoplasms; metabolism; pathology; Esophagitis, Peptic; metabolism; pathology; Female; Humans; Male; Middle Aged; Mucous Membrane; metabolism; Proto-Oncogene Proteins c-myb; metabolism
- From: Journal of Southern Medical University 2010;30(12):2693-2695
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the expression of c-myb in reflux esophagitis, Barrett esophagus and esophageal adenocarcinoma.
METHODSThe expression levels of c-myb in the esophageal mucosa tissue of patients with reflux esophagitis, Barrett esophagus and esophageal adenocarcinoma were detected by real-time fluorescent quantitative RT-PCR.
RESULTSThe expression levels of c-myb mRNA in Barrett esophagus and esophageal adenocarcinoma tissues was significantly higher than that in normal and reflux esophagitis esophageal tissue (P<0.05 or 0.01), and increased progressively with the development of reflux esophagitis into Barrett esophagus and esophageal adenocarcinoma.
CONCLUSIONSThe expression level of c-myb mRNA is closely related with the development of Barrett esophagus and esophageal adenocarcinoma, and may be used as a valuable index for monitoring the early onset and intervention of Barrett esophagus and esophageal adenocarcinoma.
