Protective effects of captopril against lung injury in rats with severe acute pancreatitis.
- Author:
Shun-le LI
1
;
Xi CHEN
;
Xin-wu ZHANG
;
Tao WU
;
Zong-zheng JI
Author Information
- Publication Type:Journal Article
- MeSH: Amylases; blood; Angiotensin II; metabolism; Animals; Captopril; pharmacology; therapeutic use; Disease Models, Animal; Lung; metabolism; pathology; Lung Injury; etiology; prevention & control; Male; Pancreatitis; complications; drug therapy; Peroxidase; metabolism; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha; metabolism
- From: Journal of Southern Medical University 2010;30(12):2742-2745
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the protective effects of captopril against lung injury in a rat model of severe acute pancreatitis (SAP).
METHODSSeventy-two male SD rats were randomized into sham-operated group (SO group), SAP group and captopril intervention group (CAP group). Serum amylase and myeloperoxidase (MPO) activity in the lung tissue were examined at 1, 6 and 12 h after the operation. TNF-α and AngII in the lung tissue were detected by ELISA, and the histopathological changes of the pancreas and lung were observed microscopically.
RESULTSThe MPO activity , which was similar between SAP group and CAP group at 1 h, were significantly lowered in CAP group at 6 and 12 h (P<0.05). Serum amylase level and the levels of TNF-α and AngII in the lung tissue homogenate were all reduced significantly in CAP group as compared to those in SAP group (P<0.01). The pathological injury of the lung was obviously lessened in CAP group in comparison with that in SAP group.
CONCLUSIONCaptopril can ameliorate SAP-induced lung injury in rats.
