hTERT single nucleotide polymorphism is associated with increased risks of hepatocellular carcinoma and tumor metastasis.
- Author:
Jin DONG
1
;
Ling WANG
;
Ya-ping TIAN
;
Yue GUO
;
Hong-ying LIU
Author Information
- Publication Type:Journal Article
- MeSH: Carcinoma, Hepatocellular; genetics; pathology; Humans; Liver Neoplasms; genetics; pathology; Male; Neoplasm Metastasis; genetics; Polymorphism, Single Nucleotide; Risk Factors; Telomerase; genetics
- From: Journal of Southern Medical University 2011;31(1):49-52
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effect of hTERT single nucleotide polymorphisms on the development and metastasis of hepatocellular carcinoma.
METHODSA total of 290 male patients were divided into hepatitis-induced primary hepatocellular carcinoma (HCC) group (n%162), metastatic HCC group (n%22), and control group (n%106). hTERT gene was amplified and hTERT single nucleotide polymorphisms (SNPs) were tested in these subjects.
RESULTSSignificant differences were found in rs2853690 and rs10069690 distribution, but the difference in rs6554743 remained uncertain. The C and T alleles of rs10069690 and rs6554743 showed significant differences between the 3 groups; the carriers of non-T allele of rs10069690 had higher frequencies in both primary and metastatic HCC groups.
CONCLUSIONSome of the polymorphisms of hTERT may increase the risks of development and metastasis of hepatocellular carcinoma.
