Pharmacokinetic study of a new chewing gum dextromethorphan delivery system.
- Author:
Juan LIU
1
;
Qun-you TAN
;
Bi-lin LIU
;
Mei-ling XU
;
Chun-jing ZHAO
;
Jing-qing ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Biological Availability; Chewing Gum; Chromatography, High Pressure Liquid; Dextromethorphan; administration & dosage; blood; pharmacokinetics; Drug Delivery Systems; Rabbits
- From: Journal of Southern Medical University 2011;31(1):103-107
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo establish an high-performance liquid chromatography (HPLC)-based method for analysis of the pharmacokinetics and relative bioavailability of dextromethorphan chewing gum tablets in rabbits.
METHODSThe pharmacokinetic parameters and the relative bioavailability of dextromethorphan chewing gum preparation in rabbits were compared with those of the commercially available chewing dextromethorphan tablets using 3P97 software.
RESULTSPharmacokinetic analysis of the new dextromethorphan chewing gum tablets showed a AUC of 488.76 ∓ 175.00 ng.ml(-1).h, C(max) of 95.45 ∓ 17.53 ng/ml, and t(max) of 1.83 ∓ 0.57 h as compared with the corresponding parameters of 370.13 ∓ 90.56 ng.ml(-1).h, 174.00 ∓ 47.88 ng.ml, and 1.04 ∓ 0.14 h for the commercially available chewing tablets. The relative bioavailability of the new chewing gum medicine system was (140.73 ∓ 65.91)%.
CONCLUSIONThe new dextromethorphan chewing gum preparation shows an increased AUC((0→)), decreased C(max), and prolonged t(max) in comparison with the commercially available chewing tablets, with also a greatly enhanced relative bioavailability.