Short-term spontaneous fluctuation of viral load in patients with chronic hepatitis B.
- Author:
Rong FAN
1
;
Jun-Hua YIN
;
Shu-Ling YANG
;
Xiao-Xi LI
;
Gao-Yang YU
;
Jian SUN
;
Jin-Lin HOU
Author Information
- Publication Type:Journal Article
- MeSH: Adult; DNA, Viral; blood; Female; Hepatitis B virus; growth & development; Hepatitis B, Chronic; virology; Humans; Liver; physiopathology; Male; Viral Load; statistics & numerical data; Young Adult
- From: Journal of Southern Medical University 2012;32(3):354-357
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the short-term spontaneous fluctuation of viral load in patients with chronic hepatitis B (CHB) and explore the related factors in treatment naive CHB patients during immune clearance phase.
METHODSA total of 123 treatment naive HBeAg-positive CHB patients with ALT>2 × ULN were enrolled in this study. Paired serum samples were obtained at the first and second visits with an interval of less than 4 weeks. The levels of quantitative HBV DNA (Roche COBAS), quantitative HBsAg, ALT and AST were analyzed. Liver biopsy specimen were collected within 4 weeks and evaluated using Knodell and Ishak histological scoring system.
RESULTSOf the 123 patients, 93 (75.6%) and 30 (24.4%) had HBV DNA fluctuation ≤ 0.5 Log IU/ml and >0.5 Log IU/ml, respectively. Binary logistic multivariate regression analysis identified Knodell necroinflammation score and HBV DNA level as the factors related to HBV DNA fluctuation. Patients with Knodell necorinflammation score ≥ 10 or HBV DNA<7 Log IU/ml had significantly higher rates of HBV DNA fluctuation>0.5 Log IU/ml (50.0% vs 18.3%, P=0.042; 42.9% vs 20.6%, P=0.030).
CONCLUSIONTreatment naive CHB patients in immune clearance phase show short-term spontaneous fluctuation of HBV DNA, and nearly 25% of the patients have HBV DNA fluctuation >0.5 Log IU/ml. Such fluctuation is related to liver inflammation and quantity of HBV DNA.