Comparison of two gastric cancer screening schemes in a high-risk population.
- VernacularTitle:胃癌高发区血清胃蛋白酶原初筛加高危人群胃镜检查方案与直接胃镜筛查方案的效果比较
- Author:
Yan-li LÜ
1
;
Yi LI
;
Guang-shun LIU
;
Qi WU
;
Wei-dong LIU
;
Shi-jie LI
;
Chang-qi CAO
;
Xiu-zhen WU
;
Dong-mei LIU
;
Lei ZHANG
;
Lan-fu ZHANG
;
Jun-ling MA
;
Kai-feng PAN
;
Lian ZHANG
;
Wei-cheng YOU
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Carcinoma; blood; diagnosis; Carcinoma in Situ; blood; diagnosis; Early Detection of Cancer; methods; Female; Gastroscopy; Humans; Male; Mass Screening; methods; Middle Aged; Pepsinogen A; blood; Stomach Neoplasms; blood; diagnosis
- From: Chinese Journal of Oncology 2013;35(5):394-397
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the effects of two gastric cancer screening schemes for early detection of gastric cancer in a high-risk population.
METHODSA cluster random sampling method was used to select local residents aged 40-69 years from Linqu County, Shandong Province. "Serum pepsinogen initial screening combined with further endoscopic examination (PG scheme)" and "direct endoscopic examination (endoscopy scheme)" were conducted. The associations between screening schemes and detection rates of gastric cancer, and early gastric cancer/high-grade intraepithelial neoplasia were evaluated by unconditional logistic regression analysis.
RESULTSOverall, 3654 and 2290 participants completed PG and endoscopy schemes, respectively. A total of 11 (0.30%) cases of gastric cancer and 10 (0.27%) cases of high-grade intraepithelial neoplasia were detected by PG scheme, of which 7 (0.19%) cases were early gastric cancer. While, 19 (0.83%) cases of gastric cancer and 10 (0.44%) cases of high-grade intraepithelial neoplasia were detected by endoscopy scheme, with 12 (0.52%) cases of early gastric cancer. Compared with the PG scheme, the endoscopy scheme had a significantly higher detection rates of gastric cancer (OR = 2.83, 95%CI 1.34-5.98), and early gastric cancer/high-grade intraepithelial neoplasia (OR = 2.12, 95%CI 1.12-4.02).
CONCLUSIONSThe endoscopy scheme is more effective in the detection of gastric cancer in a high-risk population, particularly for early gastric cancer/high-grade intraepithelial neoplasia than the PG scheme.
