Expression and prognostic value of regulatory T cells and M2 macrophages in diffuse large B-cell lymphoma tissues.
- Author:
Yuan-lin XU
1
;
Hua-qing WANG
;
Zheng-zi QIAN
;
Zheng SONG
;
Shi-yong ZHOU
;
Hui-lai ZHANG
;
Li-hua QIU
;
Xian-huo WANG
;
Ping WANG
Author Information
- Publication Type:Journal Article
- MeSH: Humans; Immunohistochemistry; Lymphoma, Large B-Cell, Diffuse; diagnosis; Macrophages; physiology; Prognosis; T-Lymphocytes, Regulatory; physiology
- From: Chinese Journal of Oncology 2013;35(6):450-455
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the prognostic value of regulatory T cells (Tregs) and M2 macrophages in diffuse large B-cell lymphoma (DLBCL) tissues.
METHODSThe expression of CD163 and Foxp3 was detected by immunohistochemistry in 92 cases of DLBCL, and it was statistically analyzed whether their expressions correlate with clinical data and prognosis in patients with DLBCL.
RESULTSThe density of M2 macrophage and regulatory T cells in DLBCL tumor tissues was significantly higher than that in the adjacent tissues (P = 0.02, P = 0.04). The expression of M2 macrophages was significantly positively correlated with regulatory T cells expression (r = 2.012, P < 0.05). High density of M2 or Tregs had a relationship with extranodal involvement (P < 0.05). Cox regression analysis showed that the expressions of CD163 and Foxp3 were independent prognostic factors of DLBCL (P < 0.05).
CONCLUSIONSCombined detection of the expression of CD163 and Foxp3 proteins and then evaluation of the amount of M2 macrophages and Tregs can be used to more closely predict the prognosis for DLBCL patients.
