Serum CEA and CA 19-9 Levels are Associated with the Presence and Severity of Colorectal Neoplasia.
10.3349/ymj.2017.58.5.918
- Author:
Nam Hee KIM
1
;
Mi Yeon LEE
;
Jung Ho PARK
;
Dong Il PARK
;
Chong Il SOHN
;
Kyuyong CHOI
;
Yoon Suk JUNG
Author Information
1. Preventive Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
CEA;
CA 19-9;
colorectal neoplasia
- MeSH:
Adenoma;
Carcinoembryonic Antigen;
Colonoscopy;
Colorectal Neoplasms;
Cross-Sectional Studies;
Humans;
Korea;
Mass Screening
- From:Yonsei Medical Journal
2017;58(5):918-924
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: Limited data are available regarding the association between circulating serum carcinoembryonic antigen (CEA) or carbohydrate antigen 19-9 (CA 19-9) concentrations and colorectal adenoma. We aimed to investigate whether elevated serum CEA and CA 19-9 levels are correlated with the presence of colorectal neoplasia (CRN) and whether the levels of these antigens vary according to CRN severity. MATERIALS AND METHODS: A cross-sectional study was performed on asymptomatic subjects who underwent colonoscopy between 2010 and 2014 as part of a comprehensive health screening program in Korea. RESULTS: A total of 124509 participants with measured serum CEA levels and 115833 participants with measured serum CA 19-9 levels were analyzed. Elevated CEA concentrations were associated with a higher rate of any adenoma, advanced adenoma, high-risk adenoma, advanced CRN (ACRN), overall CRN, and colorectal cancer (CRC). Elevated CA 19-9 concentrations were also associated with a higher rate of advanced adenoma, high-risk adenoma, ACRN, and CRC. Both elevated levels of CEA and CA 19-9 were identified as independent predictors of ACRN. Among patients with CRN, the proportions of elevated CEA/CA 19-9 levels were significantly higher in patients with ACRN than in those with non-ACRN, and these levels were correlated with larger lesion size and multiplicity of adenomas. CONCLUSION: Both elevated serum CEA and CA 19-9 levels were associated with the presence of ACRN, as well as CRC. Elevated CEA levels were also associated with the presence of overall CRN. Moreover, both CEA and CA 19-9 levels were correlated with the severity of CRN.
