Management and prognostic factors for 119 patients with follicular thyroid carcinoma.
- Author:
Wen-sheng LIU
1
;
Guo-fen ZHANG
;
Zhen-gang XU
Author Information
- Publication Type:Journal Article
- MeSH: Adenocarcinoma, Follicular; pathology; radiotherapy; secondary; surgery; Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Bone Neoplasms; secondary; Child; Female; Follow-Up Studies; Humans; Iodine Radioisotopes; therapeutic use; Lung Neoplasms; secondary; Lymph Node Excision; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Radiotherapy, Adjuvant; Retrospective Studies; Survival Rate; Thyroid Neoplasms; pathology; radiotherapy; surgery; Thyroidectomy; Young Adult
- From: Chinese Journal of Oncology 2013;35(10):778-782
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the optimal management and analyze the prognostic factors for follicular thyroid carcinoma.
METHODSThe clinicopathological data of 119 patients with well-differentiated follicular thyroid carcinoma treated in our hospital from 1970 to 2008 were retrospectively reviewed. The overall survival (OS) rate was estimated by Kaplan-Meier method. Log rank and Cox regression analyses were used to identify the prognostic factors.
RESULTSThe 5- and 10-year OS rates were 81.1% and 66.7%, respectively. The 3- , 5- and 10-year cumulative distant metastasis rates were 27.4%, 29.6% and 35.9%, respectively. The age of ≥ 45 years old was one of the most important factors affecting survival rate (P < 0.05) and an independent factor for distant matastasis.
CONCLUSIONSFollicular thyroid carcinoma has some special features such as diffuse growth and vascular tumors thrombosis and with a relatively poor prognosis. The key measure to improve local control and prognosis is radical resection. Some aggressive management such as total thyroidectomy combined with (13)1I therapy and regular follow-up should be performed to improve the survival rate and to control postoperative distant metastasis for patients ≥ 45 years old.
