Association between methylthioadenosine phosphorylase gene single nucleotide polymorphisms and myocardial infarction in Chinese Han ethnicity

VernacularTitle:甲硫腺苷磷酸化酶基因单核苷酸多态性与汉族人群心肌梗死的关系
Author: Qi ZHANG ¹ ; Shuang-Shuang CHENG ; Jie YAN ; Xing-Dong CHEN ; Xiao-Feng WANG ; Xin-Chun YANG
Author Information

1. 华北煤炭医学院附属医院
Keywords: Myocardial infarction; Methylthioadenosine phosphorylase; Single nucleotide polymorphism; Genetics
From: Chinese Journal of Epidemiology 2010;31(1):83-86
CountryChina
Language:Chinese
Abstract: Objective To investigate the association between methylthioadenosine phosphorylase (MTAP) gene single nucleotide polymorphisms (SNP) and myocardial infarction (MI) in the Chinese Han ethnicity. Methods 432 patients suffered from myocardial infarction and 430 controls were involved for case and control groups, respectively. Nine tag SNPs in MTAP gene were selected and genotyped. Results We found no significant association of selected tag SNPs with MI in all of the samples. However, in stratified analysis, significant association was observed at rs7027989 in male subjects. The risk of MI increased by 26% (P=0.005) for male subjects of minor allele carriers in a dominant model. The increased risk of MI at rs7027989 remained significant after adjusting for confounding factors. Conclusion MTAP gene might be involved in the etiology of MI in Chinese Han ethnicity.