Endothelial Progenitor Cells Correlated with Oxidative Stress after Mild Traumatic Brain Injury.
10.3349/ymj.2017.58.5.1012
- Author:
Xintao HUANG
1
;
Dahai WAN
;
Yunpeng LIN
;
Naizhao XUE
;
Jiehe HAO
;
Ning MA
;
Xile PEI
;
Ruilong LI
;
Wenju ZHANG
Author Information
1. Department of Neurosurgery, Shanxi Medical University First Affiliated Hospital, Taiyuan, China. xintaoh@hotmail.com
- Publication Type:Original Article
- Keywords:
Traumatic brain injury;
endothelial progenitor cells;
superoxide dismutase;
malonyldialdehyde
- MeSH:
Animals;
Brain Injuries*;
Cell Transplantation;
Clinical Study;
Endothelial Progenitor Cells*;
Humans;
Malondialdehyde;
Mice;
Oxidative Stress*;
Plasma;
Regeneration;
Reperfusion Injury;
Superoxide Dismutase;
Transplants;
Umbilical Cord
- From:Yonsei Medical Journal
2017;58(5):1012-1017
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: Endothelial progenitor cells (EPCs) play a key role in tissue repair and regeneration. Previous studies have shown that infusion of human umbilical cord blood-derived endothelial colony-forming cells improves outcomes in mice subjected to experimental traumatic brain injury (TBI). However, the efficiency of cell transplantation is not satisfactory. Oxidative stress plays a significant role in the survival of transplanted cells following ischemic reperfusion injury. This observational clinical study investigated the correlation between the number of circulating EPCs and plasma levels of superoxide dismutase (SOD) and malonyldialdehyde (MDA). MATERIALS AND METHODS: Peripheral blood samples were collected from 20 patients with mild TBI at day-1, day-2, day-3, day-4, and day-7 post TBI. The number of circulating EPCs and the plasma levels of SOD and MDA were measured. RESULTS: The average of circulating EPCs in TBI patients decreased initially, but increased thereafter, compared with healthy controls. Plasma levels of SOD in TBI patients were significantly lower than those in healthy controls at day-4 post-TBI. MDA levels showed no difference between the two groups. Furthermore, when assessed on day-7 post-TBI, the circulating EPC number were correlated with the plasma levels of SOD and MDA. CONCLUSION: These results suggest that the number of circulating EPCs is weakly to moderately correlated with plasma levels of SOD and MDA at day-7 post-TBI, which may offer a novel antioxidant strategy for EPCs transplantation after TBI.
