Study on molecular characteristics regarding DNA genotype of Mycobacterium tuberculosis clinical strains in Shandong

VernacularTitle:山东地区结核分枝杆菌临床菌株基因型特征研究
Author: Yun-Feng DENG ¹ ; Yan-An ZHANG ; Jian-Li ZHENG ; Hui JING ; Yan WANG ; Hai-Ying WANG ; Xin MA ; Zhi-Min LIU
Author Information

1. 山东省胸科医院
Keywords: Mycobacterium tuberculosis; Epidemiology; Genotyping; Drug resistance
From: Chinese Journal of Epidemiology 2010;31(3):321-323
CountryChina
Language:Chinese
Abstract: Objective To establish the molecular characteristics of Mycobacterium tuberculosis and on factors influencing the recent transmission of drug resistant isolates in Shandong. Methods Mycobacterium tuberculosis isolated from active pulmonary tuberculosis patients of 13 counties were genotyped by mycobacterial interspersed repetitive units (MIRU) methods. Results 12 loci of MIRU were detected in 558 isolates and a total of 143 MIRU patterns were confirmed. 66 isolates had distinct patterns,and 481 (86.2%) strains were in clusters. Shandong cluster included 177 strains with 74.6% of the isolates belonged to Beijing family. The recent transmission index of multi-drug resistance strains was in lower level,comparing to the susceptible strains. Conclusion Our results showed that the Shandong cluster isolates had capacities of facilitating person-to-person transmission and high level of drug resistance.