A community-based study on relations between metabolic syndrome and carotid atherosclerosis in a middle-aged population
10.3760/cma.j.issn.0254-6450.2010.04.001
- VernacularTitle:社区中老年人群代谢综合征与颈动脉粥样硬化的关系
- Author:
Xiao-Xuan ZOU
1
;
Ying LI
;
Hong-Ju ZHANG
;
Zuo CHEN
;
Hao WANG
;
Min GUO
;
Qian-Qian WANG
;
Lian-Cheng ZHAO
;
Ying YANG
;
Run-Ping ZHENG
;
Yu-Ling CAI
;
Dong-Feng GU
Author Information
1. 北京协和医学院中国医学科学院心血管病研究所,阜外心血管病医院
- Keywords:
Metabolic syndrome;
Carotid atherosclerosis;
Community population
- From:
Chinese Journal of Epidemiology
2010;31(4):361-365
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the association between metabolic syndromes (MS) and carotid atherosclerosis and to estimate the predictive effects of MS under 3 different definitions.Methods A cross-sectional study was conducted in 2 community-based populations in Beijing,in 2008.1266 subjects (598 men,668 women),aged 45-69,were included in the analyses.MS was defined by the criteria of International Diabetes Federation (IDF),the revised NCEPATPm (ATP Ⅲ-R) and "The Guidelines of Dyslipidemia Control for Chinese Adult" ( "Guidelines" ) in 2007.Results The prevalence rates of MS by the 3 criteria were 39.0%,43.3% and 30.9% respectively.The Kappa value for the measure of the agreement between each pair of the 3 definitions were 0.911,0.719 and 0.730 respectively.The intima-media thickness in common carotid artery (CCA-IMT) was significantly higher (P＜0.001) in all MS groups than in non-MS groups,diagnosed with the 3 criteria independent of age,gender,LDL-C,and current smoking status.After adjustment of age,gender,LDL-C,and current smoking status,the classification of MS significantly increased the risk of prevalence of carotid atberosclerotic plaques,compared to the non-MS group.OR value were 1.499 (95% CI:1.157-1.942) for IDF,1.696 (95% CI:1.314-2.189) for NCEP-R,1.763 (95% CI:1.344-2.312) for "Guideline" respectively.Conclusion Our research findings indicated that,when MS were defined with the 3 definitions,prediction on the risk of sub-clinical atberosclerosis would work beyond some of the conventional cardiovascular risk factors such as smoking,LDL-C.There might exist some differences in gender issue on the strength of association between MS when diagnosed by different criteria and carotid plaque.
