Association between the risk factors of cardiovascular diseases and Insulin resistance
10.3760/cma.j.issn.0254-6450.2010.04.002
- VernacularTitle:北京地区1359名非糖尿病人群心血管病危险因素与胰岛素抵抗的关系研究
- Author:
Miao WANG
1
;
Dong ZHAO
;
Wei WANG
;
Jing LIU
;
Jun LIU
;
Jia-Yi SUN
;
Yan LI
;
Lan-Ping QIN
;
Zhao-Su WU
Author Information
1. 首都医科大学附属北京安贞医院
- Keywords:
Cardiovascular diseases;
Risk factors;
Insulin resistance;
Homeostasis model assessment index
- From:
Chinese Journal of Epidemiology
2010;31(4):366-369
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the association between risk factors of cardiovascular diseases (CVD) and insulin resistance in a cross-sectional study.Methods An investigation on risk factors of CVD was carried out using stratified-random sampling method among 1475 participants in Beijing.Homeostasis model assessment index(HOMA) was calculated to assess the insulin resistance in 1359 non-diabetic subjects aged 25-64 years.Insulin resistance was defined as HOMA index (fasting glucose in mmol/L×fasting insulin in mU/L/22.5) in the top quartile of the studied population.Results The degree of correlation between risk factors and natural logarithm of HOMA index in descending order were glucose,body mass index (BMI),triglyceride ( TG ),waist circumstance,high density lipoprotein- cholesterol (HDL-C),uric acid,diastolic blood pressure,systolic blood pressure and total cholesterol(TC) (all P＜0.01 ).After adjusting factors as sex and age,glucose (r=0.49),BMI(r=0.44),TG (r=0.44),waist circumstance (r=0.41),uric acid (r=0.33) and HDL-C (r=-0.32),the systolic blood pressure (r=0.20),diastolic blood pressure (r=0.18) and TC (r=0.16) were independently correlated with HOMA index (P＜0.001).Sex(OR=1.75) ,low HDL-C(OR= 1.80),hyperuricemia(OR=2.11 ),high TG(OR=2.14) and central obesity(OR=2.68)appeared to be independently correlated to insulin resistance in multiple logistic regression analysis.Conclusion The risk factors of CVD as low HDL-C,high TG,central obesity and hyperuricemia were independently correlated to insulin resistance.
