A comparative study on the risks of esophagus-cancer patients among factors as blood relatives,paternal line,matriarchal and different sex
10.3760/cma.j.issn.0254-6450.2010.04.011
- VernacularTitle:食管癌患者血缘亲属及不同性别食管癌患病风险比较研究
- Author:
Yuan WANG
1
;
Xiao-You HAN
;
Ti DING
;
Yi XU
;
Quan-Hong WANG
Author Information
1. 山西省肿瘤医院
- Keywords:
Esophagus neoplasms;
Paternal line;
Matriarchal;
1st grade relative;
Risk factor
- From:Chinese Journal of Epidemiology
2010;31(4):409-412
- CountryChina
- Language:Chinese
-
Abstract:
Objective In order to provide new clues on the cause of esophagus-cancer through seeking for information among the relatives of esophagus-cancer-patients at high-risk,contrast analysis was carried out to compare the ORs between esophagus-cancer cases and the relatives of the patients.Methods Case-control study was adopted on 720 cases and 720 controls who were kin relatives of the patients.Results (1) Risk of the relatives to the esophagus-cancer-patient group ( 1.34%-2.24% ) was obviously higher than the control group (0.78%-1.21%) (P＜0.01).In 1st grade relatives,the risk of parent' s to the esophagus-cancer patients (6.11% ) was obviously higher than the control group (2.97%) (P＜0.01 ).(2) According to the cascade analysis to the cases of both paternal and matriarchal,lines,results showed that the risks of both the paternal line (0.87%-1.01%) and the matriarchal line (0.50%-0.79%) in the group of esophagus-cancer cases were all obviously higher than the lines in the control groups (0.53%-0.65%) and (0.38%-0.47%).Data also showed that the risk among the male relatives of paternal line (eg:grandfathers',father' s,uncles' etc.) in the group of cases was 2.68% while the matriarchal (eg:grandmother's,mother' s,aunts' etc.) was 1.91%.Both figures were obviously higher than that in the control group (1.50% and 0.92%,P＜0.01 ).Conclusion The risk factor of esophagus cancer of the next generation seemed higher if the father and his brothers or mother and her sisters having had esophagus-cancers.
