Effects of 14 single herbs on the induction of caspase-3 in tumor cells: a brief review.
10.1007/s11655-013-1539-y
- Author:
Hong-Yan TIAN
1
;
Zhi-Xin LI
;
Hong-Yu LI
;
Hong-Jun WANG
;
Xin-Wei ZHU
;
Zhao-Hua DOU
Author Information
1. Department of Histology and Embryology, Jilin Medical College, Jilin, Jilin Province 132013, China.
- Publication Type:Journal Article
- MeSH:
Antineoplastic Agents, Phytogenic;
pharmacology;
therapeutic use;
Apoptosis;
drug effects;
physiology;
Caspase 3;
metabolism;
Drugs, Chinese Herbal;
pharmacology;
therapeutic use;
Humans;
Neoplasms;
drug therapy;
metabolism;
Plants, Medicinal;
physiology;
Signal Transduction;
drug effects
- From:
Chinese journal of integrative medicine
2013;19(8):636-640
- CountryChina
- Language:English
-
Abstract:
Chinese medicines (CMs) are increasingly being used for the treatment of tumors because of their unique advantages. The induction of tumor cell apoptosis is an important method of tumor treatment. Caspase-3 is a member of the caspase (cysteine aspartic proteinases) family of enzymes, which are the major inducers of apoptosis. Caspase-3 activity is often measured in the context of research into anti-tumor drugs that target apoptosis. Many studies have shown that CMs upregulate the expression of caspase-3 in tumor cells via extrinsic and/or intrinsic pathways, removing endogenous suppression of apoptosis and promoting tumor cell death. Therefore, several CMs fulfill the criteria for anti-tumor drugs. In this paper, we review the efficacy of 14 Chinese herbal medicines, across a wide range applications, and discuss their effects on caspase-3 activity in tumor cells.
