Blockage of PI3K/PKB/P27kip1 signaling pathway can antagonize 17 beta-estradiol-induced Ishikawa proliferation and cell cycle progression.
- Author:
Rui-xia GUO
1
;
Li-hui WEI
;
Yu-huan QIAO
;
Jian-liu WANG
;
Jian-min TANG
Author Information
1. Department of Gynecology, People's Hospital, Peking University, BeijinG 100044, China.
- Publication Type:Journal Article
- MeSH:
Apoptosis;
drug effects;
Cell Line, Tumor;
Cell Proliferation;
drug effects;
Chromones;
pharmacology;
Cyclin-Dependent Kinase Inhibitor p27;
antagonists & inhibitors;
physiology;
Endometrial Neoplasms;
drug therapy;
pathology;
Estradiol;
pharmacology;
Female;
G1 Phase;
drug effects;
Humans;
Intracellular Signaling Peptides and Proteins;
antagonists & inhibitors;
physiology;
Morpholines;
pharmacology;
Phosphatidylinositol 3-Kinases;
antagonists & inhibitors;
physiology;
Proto-Oncogene Proteins c-akt;
antagonists & inhibitors;
physiology;
Signal Transduction;
drug effects;
physiology
- From:
Chinese Medical Journal
2006;119(3):242-245
- CountryChina
- Language:English
