Transdermal behavior of effective constituents in xuanbi gel plaster.
- Author:
Yuehuan LIU
1
;
Yang LU
;
Shouying DU
;
Jie BAI
;
Yue WANG
;
Huiyun LI
Author Information
- Publication Type:Journal Article
- MeSH: Administration, Cutaneous; Animals; Flavanones; metabolism; Gels; chemistry; Iridoid Glucosides; metabolism; Male; Phenols; metabolism; Rats; Rats, Sprague-Dawley; Skin Absorption
- From: China Journal of Chinese Materia Medica 2012;37(9):1202-1205
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the transdermal absorbability of gentiopicroside, naringin and protosappanin B contained in Xuanbi gel plaster.
METHODThe Franz diffusing cells method was adopted for the in vitro model of rat belly skins. Three indexes, gentiopicroside, naringin and protosappanin B, residued in the accept liquid, skins and plaster were determined by HPLC.
RESULTThe penetration rates of gentiopicroside, naringin and protosappanin B were respectively 3.47, 1.59, 2.13 microg x cm(-2) x h(-1). After 24 h, their penetration rates were 25.42%, 11.73%, 17.78%, respectively. The residual quantities of gentiopieroside, naringin and protosappanin B in skin were 0.231, 0.593, 0.568 microg x cm(-2), ith the retention rates of 0.027%, 0.227%, 0.475%, respectively. The amount of residue of gentiopicroside, naringin and protosappanin B in plaster were 2179, 674, 278 microg, with the retention rates of 81.36%, 81.92%, 73.83%, respectively.
CONCLUSIONThe in vitro transdermal behavior of Xuanbi gel plaster is close to a zero-order process. The residual quantity the retention rate in skins is much lower than the penetration rate and the residual rate in plaster.
