Effect of different compatibility of tetramethylpyrazine on its pharmacokinetics in vivo.
- Author:
Binbin FENG
1
;
Jianhai ZHANG
;
Jifen ZHANG
;
Gang CHEN
;
Xiaoyu XU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Chromatography, High Pressure Liquid; Coumaric Acids; pharmacokinetics; Diterpenes; pharmacokinetics; Drug Interactions; Female; Pyrazines; pharmacokinetics; Random Allocation; Rats; Rats, Sprague-Dawley
- From: China Journal of Chinese Materia Medica 2012;37(9):1311-1314
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the pharmacokinetics of single administration and different compatibility of tetramethylpyrazine (TMP) in rats.
METHODThirty two Sprague-Dawley rats were randomly divided into 4 groups: the TMP (30 mg x kg(-1)) group, the TMP+FA (30 mg x kg(-1) + 50 mg x kg(-1)) group, the TMP+TET (30 mg x kg(-1) mg x kg(-1)) group and the TMP+FA+TET (30 mg x kg(-1) + 50 mg x kg(-1) + 20 mg x kg(-1)) group. After the oral administration, their blood samples were collected to detect plasmas concentrations by HPLC method and to calculate pharmacokinetic parameters DAS 2.0 program.
RESULTIn compatibility with FA, AUC(0-t), Cmax and Tmax showed no significant difference with the single administration of TMP, but t(1/2) and MRT,, were obviously longer than the single administration. In compatibility with TET and FA + TET, AUC (0-t), Cmax and Tmax showed significant increase than the single administration of TMP, whereas t(1/2) and MRT0, did not notably vary from the single administration.
CONCLUSIONFA can prolong TMP's action time in rats, and TET can accelerate TMP's absorption in rats.
