Study on solid dispersion of binary vector of tanshinone II A.
- Author:
Yanrong JIANG
1
;
Zhenhai ZHANG
;
Yan LU
;
Jing TANG
;
Tiantian MA
;
Xiaobin JIA
Author Information
- Publication Type:Journal Article
- MeSH: Calorimetry, Differential Scanning; Diterpenes, Abietane; chemistry; Drug Stability; Drugs, Chinese Herbal; chemistry; Solubility
- From: China Journal of Chinese Materia Medica 2012;37(10):1383-1387
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo prepare the solid dispersion of tanshinone II A (TS II A) by the combined application of nano-silica and poloxamer 188 (F68), in order to observe its dissolution and stability.
METHODTanshinone II A solid dispersion was prepared by the solvent method with nano-silica and poloxamer 188 as binary vectors. Its physical characteristics, in vitro dissolution and stability were further assessed.
RESULTThe tanshinone II solid dispersion was prepared with the weight ratio of nano-silica and poloxamer 188 of 1: 3. The differential scanning calorimetry (DSC) demonstrated that Tanshinone II A existed in vectors as amorphous state. The in vitro dissolution of tanshinone II A solid dispersion is up to 90% at 60 min. Accelerating experiment showed that content and in vitro dissolution of tanshinone II A solid dispersion did not change after storage over 3 months.
CONCLUSIONSolid dispersion of binary vector of tanshinone II A can obviously improve the dissolution and stability of tanshinone II in practice.
