Experimental study on effect of combination of Epimedii Folium/ Ligustri Lucidi Fructus and dexamethasone on asthmatic rats.
- Author:
Renhui LIU
1
;
Liping XU
;
Xiujuan WANG
;
Jing YANG
;
Pei WANG
;
Liang PAN
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Asthma; drug therapy; immunology; Bronchoalveolar Lavage Fluid; immunology; Cytokines; analysis; Dexamethasone; administration & dosage; Drug Therapy, Combination; Drugs, Chinese Herbal; administration & dosage; Ligustrum; Male; Rats; Rats, Sprague-Dawley; Th1 Cells; immunology; Th2 Cells; immunology
- From: China Journal of Chinese Materia Medica 2012;37(10):1497-1499
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the anti-inflammatory effect of the combination of Epimedii Folium, Ligustri Lucidi Fructus and dexamethasone on asthma and its effect in inhibiting adverse reaction against hormone.
METHODDexamethasone had been injected intraperitoneally into asthmatic model rats for 2 weeks, together with the oral administration of Epimedii Folium and Ligustri Lucidi Fructus. The contents of IL-4, INF-gamma, IL-5 and GCR in BALF, serum COR, plasma ACTH and hypothalamic CRH were observed.
RESULTThe combination of Epimedii Folium, Ligustri Lucidi Fructus and dexamethasone can significantly decrease the contents of IL-5 and IL-4 in BALF and ACTH and CRH content in plasma, increase the content of IFN-gamma and GCR in BALF and balance Th1/Th2.
CONCLUSIONThe combination of Epimedii Folium, Ligustri Lucidi Fructus and dexamethasone has a better anti-inflammatory effect on asthmatic model rats, and play a protective role in the pathway of endogenous dexamethasone.
