Effects of guizhi tang on inflammatory cytokines in myocardial ischemia and hyperlipidemia rats.
- Author:
Hong JIAO
1
;
Jianwei MA
;
Yanjing CHEN
;
Dahong JU
;
Lihua XIANG
;
Shuqiang WANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; C-Reactive Protein; metabolism; Cytokines; metabolism; Drugs, Chinese Herbal; pharmacology; Hyperlipidemias; blood; metabolism; pathology; Inflammation; metabolism; Male; Malondialdehyde; blood; metabolism; Myocardial Ischemia; blood; metabolism; pathology; Myocardium; metabolism; pathology; Nitric Oxide; metabolism; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; blood; metabolism; Tumor Necrosis Factor-alpha; metabolism
- From: China Journal of Chinese Materia Medica 2012;37(11):1634-1637
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the effects of Guizhi Tang on the inflammatory cytokines in myocardial ischemia and hyperlipidemia rats.
METHODThe early changes of hyperlipid and atherosclerosis are caused by utilizing multiple factors including feeding hyperlipid and propylthiouracil and high doses of vitamin D3 for 12 weeks. Sixty male SD rats were randomly divided in to 5 groups: control group, model group, simvastatin group, low-dosage Guizhi Tang group, high-dosage Guizhi Tang group. At the end of six weeks treatment, pituitrin(pit) is abdominal cavity injected every 24 hours for a total of three times. Detecting the serum levels of SES, CRP, NO, SOD, MDA and the content of cardiac muscle tissue SOD, MDA, The expression of TNF-alpha in cardiac muscle tissue was detected by immunohistochemistry.
RESULTGuizhi Tang significantly decreased levels of SES, CRP and MAD, increased levels of NO and SOD, Guizhi Tang markedly decreased the level of protein expression of TNF-alpha in cardiac muscle tissue.
CONCLUSIONGuizhi Tang may inhibit the proinflammatory factors and oxidation in myocardial ischemia and hyperlipidemia rats.
