Effect of the purariae-isofiavones on estrogen level in normal and ovariectomized rats.
- Author:
Ben-ling QI
1
;
Ben-ming QI
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Estradiol; blood; Estriol; blood; Estrogen Antagonists; pharmacology; Female; Gonadotropin-Releasing Hormone; blood; Isoflavones; isolation & purification; pharmacology; Ovariectomy; Plants, Medicinal; chemistry; Pueraria; chemistry; Rats; Rats, Sprague-Dawley
- From: China Journal of Chinese Materia Medica 2002;27(11):850-852
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the effect of purariae isoflavone on estrogen level in ovariectomized rats.
METHOD80 rats were divided into four groups randomly, every group with 20 rats: 1. Control group; 2. Normal + purariae isoflavone group; 3. Ovariectomized group; 4. Ovariectomized + purariae isoflavone group. Estrogen level and gonadotropin-releasing hormone level of all rats were measured.
RESULTThirty days after being ovariectomized, E2, E3 level was significantly lower than that of the first group(P < 0.05). But Testerone, FSH, LH, PRL and GH increased(P < 0.05). After being gastrogavaged with purariae-isolfavone for thirty days, Estrogen level and gonadotropin-relasing hormone level of the second group were significantly lower in various degree than those of normal control group (P < 0.05). But in ovariectomized rats, the estrogen level was recovered (P > 0.05). The gonadotropin-releasing hormone level was increased (P < 0.05).
CONCLUSIONPurariae-isoflavone can increase estrogen level to normal in ovariectomized rats by way of increasing the level of gonadotropin-releasing hormone. In normal rats, it has anti-estrogen effect.
