Depressive effect of total flavonoid fraction of Asttragalus complanatus R. Br and its influence upon hemodynamics in SHR.
- Author:
Bing XUE
1
;
Jing-xin LI
;
Lian-bi CHEN
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Antihypertensive Agents; pharmacology; Astragalus Plant; chemistry; Blood Pressure; drug effects; Cardiac Output; drug effects; Drugs, Chinese Herbal; isolation & purification; pharmacology; Female; Flavonoids; isolation & purification; pharmacology; Heart Rate; drug effects; Hemodynamics; drug effects; Hypertension; physiopathology; Male; Plants, Medicinal; chemistry; Rats; Rats, Inbred SHR; Vascular Resistance; drug effects
- From: China Journal of Chinese Materia Medica 2002;27(11):855-858
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate effects of total flavonoid fraction of Asttragalus complanatus on blood pressure in conscious spontaneously hypertensive rats(SHR) and hemodynamics in anesthetized SHR.
METHODBlood pressure was recorded with tail-culf method and hemodynamics was recorded with polygraph after administration of total flavonoid fraction of Asttragalus complanatus.
RESULTTotal flavonoid fraction of Asttragalus complanatus (100, 200 mg.kg-1) could decrease blood pressure of conscious SHR(decreasing 7.1%, P < 0.05 and 9.3%, P < 0.01 respectively). Meanwhile, there was no significant change in heart rate(HR). R Br (200 mg.kg-1) could decrease total peripheral resistance (TPR) (decreasing 20%, P < 0.05) but did not influence the cardiac output(CO) and heart rate in anesthetized SHR.
CONCLUSIONTotal flavonoid fraction of Asttragalus complanatus possesses obvious hypotensive effect, mainly by means of decreasing the TPR.
