Anti-emetic effect of ethanol extract from "Wuzhuyu broth".
- Author:
Ting ZHANG
1
;
Min-wei WANG
;
Si-wei CHEN
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Antiemetics; therapeutic use; Columbidae; Drug Combinations; Drugs, Chinese Herbal; isolation & purification; therapeutic use; Evodia; chemistry; Female; Gastric Emptying; drug effects; Male; Mice; Muscle Contraction; drug effects; Phytotherapy; Plants, Medicinal; chemistry; Rats; Rats, Sprague-Dawley; Vomiting; drug therapy
- From: China Journal of Chinese Materia Medica 2002;27(11):862-866
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the anti-emetic effect of ethanol extract from "WuZhuYu broth" and its mechanism.
METHODThree experiments were carried out test which extract has anti-emetic activity, such as CuSO4-induced pigeon's emetic response, gastric emptying in mice and ACh-induced or 5-HT-induced contraction in vitro gastric muscle in rats. Meanwhile, effect of anti-emetic extract on concentration-response curve to ACh, 5-HT, histamine was investigated.
RESULT50% ethanol extract and 70% ethanol extract were identified as having significantly stronger anti-emetic activities with little side effect, which showed the significant effect on concentration-response curve to ACh, 5-HT, histamine.
CONCLUSION50% ethanol extract and 70% ethanol extract contain more anti-emetic fractions, more anti-emetic fractions can be gained at the concentrations of 50% and 70% ethanol; the mechanism of anti-emetic effect is related to its antagonism to the receptors of ACh, 5-HT, histamine.
